Bystanders can safely and legally spray naloxone into the nose or inject it into a muscle.
Into the nose (intranasal spray):
Narcan® Nasal Spray is available by prescription from all authorized prescribers.
The applicator for Narcan® Nasal Spray is placed gently into the nostril and sprayed via the attached plunger. First responders often give naloxone intranasally.
Into the muscle (intramuscular injection):
The naloxone should be injected into the upper arm muscle (the deltoid) or the outer thigh. In an emergency, it is safe to inject through clothing.